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About

Comprehensive atlas for regulatory elements and functional annotations


Dataset Available

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Mouse Brain

Species: Mus musculus
Sample: 45 brain sub-regions
Method: snATAC-seq
Nuclei count: > 800,000

Last updated May,2020

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Human Tissues

Species: Homo Sapiens
Samples: 30 adult tissues
Method: snATAC-Seq
Cell counts: >1.3 million

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Human Heart

Species: Homo Sapiens
Samples: Left/right Atria and ventricules from 4 donors
Method: snATAC-Seq and snRNA-Seq
Cell counts: 80K snATAC cells and 36K snRNA cells

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Mouse Cortex

Species: Mus musculus
Samples: Frontal cortex & hippocampus
Method: Paired-Tag
Cell counts: 64,849

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Human Brain

Species: Homo Sapiens
Samples: 42 brain regions
Method: snATAC-seq
Cell counts: >1.1 million

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Coming soon

About

We hope you find this data resource useful. Please write us with experiences and suggestions. We would love stories about how people are using it in their work.

Summary

We provide comprehensive reference maps of cis-regulatory elements identified from single-cell epigenetic datasets. You can explore cell clusters from different tissues and organisms, detailed annotations for every cell types, and genomic signal tracks and functional predictions.


Publications


2021

A single-cell atlas of chromatin accessibility in the human genome

Kai Zhang*, James D. Hocker*, Michael Miller, Xiaomeng Hou, Joshua Chiou, Olivier B. Poirion, Yunjiang Qiu, Yang E. Li, Kyle J. Gaulton, Allen Wang, Sebastian Preissl, Bing Ren.
Cell, 2021. doi:https://doi.org/10.1016/j.cell.2021.10.024


An Atlas of Gene Regulatory Elements in Adult Mouse Cerebrum

Yang Eric Li*, Sebastian Preissl*, Xiaomeng Hou, Ziyang Zhang, Kai Zhang, Yunjiang Qiu, Olivier Poirion, Bin Li, Joshua Chiou, Hanqing Liu, Antonio Pinto-Duarte, Naoki Kubo, Xiaoyu Yang, Rongxin Fang, Xinxin Wang, Jee Yun Han, Jacinta Lucero, Yiming Yan, Michael Miller, Samantha Kuan, David Gorkin, Kyle Gaulton, Yin Shen, Michael Nunn, Eran A. Mukame, M. Margarita Behrens, Joseph Ecker and Bing Ren.
Nature, 2021. doi:https://doi.org/10.1038/s41586-021-03604-1


Cardiac Cell Type-Specific Gene Regulatory Programs and Disease Risk Association

James D Hocker, Olivier B Poirion, Fugui Zhu, Justin Buchanan, Kai Zhang, Joshua Chiou, Tsui-Min Wang, Qingquan Zhang, Xiaomeng Hou, Yang Eric Li, Yanxiao Zhang, Elie Farah, Allen Wang, Andrew D McCulloch, Kyle J Gaulton, Bing Ren#, Neil C Chi#, Sebastian Preissl#
Science Advances, 2021. doi:10.1126/sciadv.abf1444


2018

Single-nucleus analysis of accessible chromatin in developing mouse forebrain reveals cell-type-specific transcriptional regulation

Sebastian Preissl*, Rongxin Fang*, Hui Huang, Yuan Zhao, Ramya Raviram, David U. Gorkin, Yanxiao Zhang, Brandon C. Sos, Veena Afzal, Diane E. Dickel, Samantha Kuan, Axel Visel, Len A. Pennacchio, Kun Zhang, Bing Ren.
Nature Neuroscience, 2018. doi:10.1038/s41593-018-0079-3


Contributes


Contact

  • RENlab
    Laboratory of Gene Regulation
    View Homepage
    • Lab location: 9500 Gilman Dr, CMME #2071, La Jolla, CA-92093, USA (Ludwig Institute for Cancer Research, San Diego)
      Lab phone: +1-858-822-5767
      Fax: +1-858-534-7750

      Web Maintenance:
      Yang (Eric) Li < yal054 AT health.ucsd.edu >
      Bin Li < bil022 AT ucsd.edu >