CATlas Resource - Human Multi-tissues
Publications
Kai Zhang*, James D. Hocker*, Michael Miller, Xiaomeng Hou, Joshua Chiou, Olivier B. Poirion, Yunjiang Qiu, Yang Eric Li, Kyle J. Gaulton, Allen Wang, Sebastian Preissl, Bing Ren. A single-cell atlas of chromatin accessibility in the human genome.Cell. 2021 Nov 24;184(24):5985-6001.e19. doi: 10.1016/j.cell.2021.10.024
Sample Informations
Current catalogs of regulatory sequences in the human genome are still incomplete and lack cell type resolution. To profile the activity of gene regulatory elements in diverse cell types and tissues in the human body, we applied single-cell chromatin accessibility assays to 30 adult human tissue types from multiple donors. We integrated these datasets with single-cell chromatin accessibility data from 15 fetal tissue types to reveal the status of open chromatin for approximately 1.2 million candidate cis-regulatory elements (cCREs) in 222 distinct cell types comprised of >1.3 million nuclei. We used these chromatin accessibility maps to delineate cell type-specificity of fetal and adult human cCREs and to systematically interpret the noncoding variants associated with complex human traits and diseases. This rich resource provides a foundation for the analysis of gene regulatory programs in human cell types across tissues, life stages, and organ systems.
Cell types
| Cell class | Cell class name | Cell type | Cell type name |
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Signal tracks
Normalized (signal per million reads) fragment pileup profiles (bigwig format) for each cell type.
Generate by MACS2 with "--SPMR" parameter
Candidate cis- regulatory elements (cCREs)
Robust and reproducible candidate cis- regulatory elements (cCREs) in bed format. We provide a union set of cCREs and cCREs in each cell type.
Coming Soon....Supplementary Tables
Supplementary info for nuclei, cell types, cCREs, motif enrichment, etc.
Coming Soon....Deep Learning Prediction Results
Coming Soon....